Not extensively tested, but as of Lion DP4, seems to work fine.
Edit: There are problems with stuttering while working when using an Intuos tablet. This issue will probably exist also with other tablets. Not sure if it's the tablet's driver, Lion's graphics driver or an issue with ZBrush, but right now it's almost unusable when using one of those tablets.
Edit 2: The problem can be fixed to a certain degree when using the newest Wacom driver and disabling multi-draw in ZBrush. After that, the stuttering happens a lot less.
Edit 3: The problem seems to be related to Wacom's Drivers. When drivers are completely uninstalled, the pen works normally in ZBrush, except the pen loses functionality (i.e. it becomes a "mouse").